The biggest New England layoffs this fall, from HubSpot to Dartmouth Health

Since August, employers across New England have announced cuts touching well over 1,000 jobs, from Cambridge tech and biotech to hospitals in New Hampshire and Vermont. Here is what has been confirmed, company by company, and what the numbers do and don't mean.

The 30-second version

• HubSpot is cutting nearly 660 jobs worldwide (about 7%).
• Sanofi is laying off 229 Massachusetts workers at Blueprint Medicines.
• Frugal Fannie's in Westwood is closing, affecting 214 jobs.
• Dartmouth Health laid off 124 people and eliminated 303 open positions.
• UVM Health is affecting 199 positions, 144 net after new roles.
• TScan Therapeutics in Waltham filed notice for 96 jobs.
• CLYNK is closing its Biddeford, Maine plant, affecting 54 jobs.

HubSpot, Cambridge, Mass.

HubSpot announced October 6 that it would cut nearly 660 employees, about 7% of its workforce, as it reorganizes around its AI strategy and removes management layers. CEO Yamini Rangan said the cuts were not driven by AI efficiencies. The company has not said how many Massachusetts workers are affected. (HubSpot, Boston Globe)

Sanofi and Blueprint Medicines, Cambridge, Mass.

Sanofi filed a state layoff notice August 7 covering 229 Massachusetts jobs at Blueprint Medicines, which it acquired. Cuts run from October 9 through late June 2027, two former Blueprint locations will close, and remaining staff move to Cambridge Crossing. Sanofi cited integration and aligning with its priorities. (Mass. WARN updates, Boston Globe)

TScan Therapeutics, Waltham, Mass.

The cancer-therapy company announced September 2 that it would cut roughly 75% of its workforce, pause Phase 3 enrollment for lack of capital, and focus on solid-tumor work. Its state notice lists 96 Waltham jobs, effective November 2. Those are two measures of the same cut, not separate ones. (SEC filing)

Frugal Fannie's, Westwood, Mass.

The off-price clothing store is closing its Westwood flagship after 43 years, with 214 jobs affected and layoffs beginning November 23. The company cited health considerations, key staff retirements, and a lease ending without renewal options. (Patch, company release)

Dartmouth Health, Lebanon, N.H.

Dartmouth Health said September 15 it laid off 124 employees and eliminated 303 vacant positions at Dartmouth Hitchcock Medical Center and Southern Region clinics. That is 124 layoffs, not 427. The system pointed to a 12% rise in operating expenses and slower insurer payments. (Valley News, WCAX)

UVM Health, Burlington, Vt.

UVM Health announced September 15 that 199 positions across Vermont and northern New York are affected, with 55 new roles created, for 144 net positions removed. Of those, 118 are at UVM Medical Center in Burlington. The system expects about $16.8 million in savings and gave workers a 45-day transition. Not every affected position means a person losing a job. (UVM Health)

CLYNK, Biddeford, Maine

The bottle redemption company filed notice September 9 that it is closing its Biddeford processing plant, affecting 54 jobs, as it modernizes and relocates Maine processing. (Maine Public)

Worth knowing: notices that aren't new layoffs

• Hasbro, Pawtucket, R.I.: An October 8 state notice covers 587 Rhode Island positions, but every employee was offered a job at the new Boston headquarters. Hasbro said it is not a new layoff; the move was first announced in September 2025. (Boston Globe)
• IDEX Health & Science, Bristol, Conn.: An October 1 update pushed 44 separations to December 31 for a plant closure first announced in May. (Connecticut DOL notice)

The bigger picture

Massachusetts reported August unemployment of 4.3%, down from July, even as payroll jobs fell by 7,100. Those are statewide estimates and don't measure these announcements directly. (Mass.gov)

If you've been laid off

Massachusetts residents can file for unemployment and find job help through MassHire. Every New England state runs a similar career center network.

Cover: AI-generated editorial illustration, not a real office.